Publications

  • 49. Peroxide-Initiated Hydrophosphination of gem-Difluoroalkenes

    Intelli, A. J.; Lee, R. T.; Altman, R. A.*

    J. Org. Chem. 2023, 88, 19, 14012-14021.

    Synthetic Fluorination Methodology, Fluorinated Alkenes

  • 48. Palladium-Catalyzed Dearomatization of Benzothiophenes: Isolation and Functionalization of a Discrete Dearomatized Intermediate

    Intelli, A. J.; Pal, M.; Selvaraju, M.; Altman, R. A.*

    Synthesis 2023; 55, 21, 3568-3574.

    Synthetic Fluorination Methodology, Palladium Catalysis, C—H Functionalization

  • 47. A Diselenide Additive Enables Photocatalytic Hydroalkoxylation of gem-Difluoroalkenes

    Herrick, R. M.; Abd El-Gaber, M. K.; Rodriguez, L. G. C.; Altman, R. A.*

    Chem. Commun. 2023, 59, 5623–5626.

    Synthetic Fluorination Methodology, Fluorinated Alkenes

  • 46. Photocatalytic Hydrothiolation of gem-Difluoroalkenes

    Sorrentino, J. P.; Herrick, R. M.; Abd El-Gaber, M. K.; Abdelazem, A. Z.; Altman, R. A.*

    J. Org. Chem. 2022, 87, 16676–16690.

    Synthetic Fluorination Methodology, Fluorinated Alkenes

  • 45. Cu(II)-Catalyzed Oxidation of gem-Difluoroalkenes Generate α,α-Difluorinated-α-Phenoxyketones

    Koley, S.; Cayton, K. T; González-Montiel, G. A.; Yadav, M. R.; Orsi, D. L.; Intelli, A. J; Cheong, P. H.-Y.;* Altman, R. A.*

    J. Org. Chem. 2022, 87, 10710–10725.

    Synthetic Fluorination Methodology, Fluorinated Alkenes

  • 42. Fluorine-Retentive Strategies for the Functionalization of gem-Difluoroalkenes

    Sorrentino, J. P.; Altman, R. A.*

    Synthesis 2021, 53, 21, 3935-3950.

    Synthetic Fluorination Methodology, Fluorinated Alkenes

  • 41. Acid-catalyzed Hydrothiolation of gem-Difluorostyrenes to Access α,α-Difluoroalkylthioethers

    Sorrentino, J. P.; Orsi, D. L.; Altman, R. A.*

    J. Org. Chem. 2021, 86, 2297–2311.

    Synthetic Fluorination Methodology, Fluorinated Alkenes

  • 39. Arylation of gem-difluoroalkenes using a Pd/Cu Co-catalytic system that avoids β-fluoride elimination

    Yuan, K; Feoktistova, T.; Cheong, P. H.-Y.;* Altman, R. A.*

    Chem. Sci. 2021, 12, 1363–1367.

    Synthetic Fluorination Methodology, Fluorinated Alkenes

  • 38. Cobalt-Catalyzed Selective Unsymmetric Dioxidation of β,β-Difluorostyrenes

    Orsi, D. L.; Sorrentino, J. P.; Douglas, J. T.; Altman, R. A.*

    J. Org. Chem. 2020, 85, 10451–10465.

    Synthetic Fluorination Methodology, Fluorinated Alkenes

  • 36. Recent Advances in Transition Metal Catalyzed Functionalization of gem-Difluoroalkenes

    Koley, S.; Altman, R. A.*

    Isr. J. Chem. 2020, 60, 313–339.

    Synthetic Fluorination Methodology, Fluorinated Alkenes, Reviews

  • 33. BBDFA: A Practical Reagent for Trifluoromethylation of Allylic and Benzylic Alcohols on Preparative Scale

    Han, C.;* Alabanza, L. M.; Kelly, S. M.; Orsi, D. L.; Gosselin, F.; Altman, R. A.*

    Org. Proc. Res. Dev. 2019, 23, 1695–1702.

    Synthetic Fluorination Methodology, Decarboxylative Coupling

  • 32. Organocatalytic Strategy for Hydrophenolation of Gem-Difluoroalkenes

    Orsi, D. L.; Yadav, M. R.; Altman, R. A.*

    Tetrahedron 2019, 75, 4325–4336.

    Synthetic Fluorination Methodology, Fluorinated Alkenes

  • 30. Catalytic One-Step Deoxytrifluoromethylation of Alcohols

    de Azambuja, F.; Lovrien, S. K.; Ross, P.; Ambler, B. R.; Altman, R. A.*

    J. Org. Chem. 2019, 84, 2061–2071.

    Synthetic Fluorination Methodology, Decarboxylative Coupling

  • 26. Exploiting the Unusual Effects of Fluorine in Methodology

    Orsi, D. L.; Altman, R. A.*

    Chem. Commun. 2017, 53, 7168–7181.

    Synthetic Fluorination Methodology, Reviews

  • 25. Base Catalysis Enables Access to α,α-Difluoroalkylthio-ethers

    Orsi, D. L.; Easley, B. J.; Lick, A. M.; Altman, R. A.*

    Org. Lett. 2017, 19, 1570–1573.

    Synthetic Fluorination Methodology, Fluorinated Alkenes

  • 22. Palladium Catalysis Enables Benzylation of α,α-Difluoroketone Enolates

    Yang, M.-H.; Hunt, J. R.; Sharifi, N. Altman, R. A.*

    Angew. Chem. Int. Ed. 2016, 55, 9080–9083.

    Synthetic Fluorination Methodology, Decarboxylative Coupling

  • 21. Copper-Catalyzed Synthesis of Trifluoroethylarenes from Benzylic Bromodifluoroacetates

    Ambler, B. R.; Zhu, L.; Altman, R. A.*

    J. Org. Chem. 2015, 80, 8449–8457.

    Synthetic Fluorination Methodology, Decarboxylative Coupling

  • 20. Ligand-controlled Regioselective Cu-Catalyzed Trifluoromethylation to Generate Trifluoromethyl Allenes

    Ambler, B. R.; Peddi, S.; Altman, R. A.*

    Org. Lett. 2015, 17, 2506–2509.

    Synthetic Fluorination Methodology, Decarboxylative Coupling

  • 19. Ligand-Controlled Regiodivergent Palladium-catalyzed Decarboxylative Allylation Reaction to Access α,α-Difluoroketones

    Yang, M.-H.; Orsi, D.; Altman, R. A.*

    Chem. Int. Ed. 2015, 54, 2361–2365.

    Synthetic Fluorination Methodology, Decarboxylative Coupling

  • 18. Metal-free Trifluoromethylation of Aromatic and Heteroaromatic Aldehydes and Ketones

    Qiao, Y.; Si, T.; Yang, M.-H.; Altman, R. A.*

    J. Org. Chem. 2014, 79, 7122–7131.

    Synthetic Fluorination Methodology, Decarboxylative Coupling

  • 17. Copper-catalyzed Conversion of Propargylic Bromodifluoroacetates to Trifluoromethanes

    Ambler, B. R.; Peddi, S.; Altman, R. A.*

    Synthesis 2014, 46, 1938–1946.

    Synthetic Fluorination Methodology, Decarboxylative Coupling

  • 16. Decarboxylative Fluorination Strategies for Accessing Medicinally-Relevant Products

    Qiao, Y.; Ambler, B. R.; Zhu, L.; Altman, R. A.*

    Curr. Top. Med. Chem. 2014, 14, 966–978.

    Synthetic Fluorination Methodology, Decarboxylative Coupling, Medicinal Chemistry, Fluorination in Medicinal Chemistry, Reviews

  • 15. Copper-Catalyzed Trifluoromethylation of Allylic Bromodifluoroacetic Esters

    Ambler, B. R.; Altman, R. A.*

    Org. Lett. 2013, 15, 5578–5581.

    Synthetic Fluorination Methodology, Decarboxylative Coupling

  • 14. Copper-Mediated Deoxygenative Trifluoromethylation of Benzylic Xanthates: Formation of C(sp3)–CF3 from an O-Based Electrophile

    Zhu, L.; Liu, S.; Douglas, J. T.; Altman, R. A.*

    Chem. Eur. J. 2013, 19, 12800–12805.

    Synthetic Fluorination Methodology

  • 13. Preparation of Fluoroalkenes via the Shapiro Reaction: Direct Access to Fluorinated Peptidomimetics

    Yang, M. H.; Matikonda, S. S.; Altman, R. A.*

    Org. Lett. 2013, 15, 3894–3897.

    Synthetic Fluorination Methodology, Fluorinated Alkenes