23. Metal-catalyzed Decarboxylative Fluoroalkylation Reactions

ReviewsOrganofluorine MethodologyDecarboxylative and Deoxygenative Fluoroalkylation CouplingSynthetic Organic Methodology
Written By Altmaniacs
 
 

Ambler, B. R.; Yang, M.-H.; Altman, R. A.*

Synlett 2016, 27, 2747–2755.

Metal-catalyzed decarboxylative fluoroalkylation reactions enable the conversion of simple O-based substrates into biologically relevant fluorinated analogues. Herein, we present decarboxylative methods that facilitate the synthesis of trifluoromethyl- and difluoroketone-containing products. We highlight key mechanistic aspects that are critical for efficient catalysis, and that inspired our thinking while developing the reactions.

Altmaniacs
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22. Palladium Catalysis Enables Benzylation of α,α-Difluoroketone Enolates