Fluorinated Alkenes

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54. Synthesis of 4-(2,2-Difluorovinyl)benzonitrile through a Wittig-type Olefination of 4-Formylbenzonitrile
54. Synthesis of 4-(2,2-Difluorovinyl)benzonitrile through a Wittig-type Olefination of 4-Formylbenzonitrile

Andrew J. Intelli, Jacob P. Sorrentino, and Ryan A. Altman*

Org. Synth. 2024, 101, 542. DOI: 10.15227/orgsyn.101.0542.

51. Palladium and Copper Co-Catalyzed Chloro-Arylation of gem-Difluorostyrenes – Use of a Nitrite Additive to Suppress β-F Elimination
51. Palladium and Copper Co-Catalyzed Chloro-Arylation of gem-Difluorostyrenes – Use of a Nitrite Additive to Suppress β-F Elimination

Intelli, A. J.; Wayment, C. Z.; Lee, R. T.; Yuan, K.; Altman, R. A.*

Chem. Sci., 2024,15, 17571-17578.

49. Peroxide-Initiated Hydrophosphination of gem-Difluoroalkenes
49. Peroxide-Initiated Hydrophosphination of gem-Difluoroalkenes

Intelli, A. J.; Lee, R. T.; Altman, R. A.*

J. Org. Chem. 2023, 88, 19, 14012–14021.

47. A Diselenide Additive Enables Photocatalytic Hydroalkoxylation of gem-Difluoroalkenes
47. A Diselenide Additive Enables Photocatalytic Hydroalkoxylation of gem-Difluoroalkenes

Herrick, R. M.; Abd El-Gaber, M. K.; Rodriguez, L. G. C.; Altman, R. A.*

Chem. Commun. 2023, 59, 5623–5626.

46. Photocatalytic Hydrothiolation of gem-Difluoroalkenes
46. Photocatalytic Hydrothiolation of gem-Difluoroalkenes

Sorrentino, J. P.; Herrick, R. M.; Abd El-Gaber, M. K.; Abdelazem, A. Z.; Altman, R. A.*

J. Org. Chem. 2022, 87, 16676–16690.

45. Cu(II)-Catalyzed Oxidation of gem-Difluoroalkenes Generate α,α-Difluorinated-α-Phenoxyketones
45. Cu(II)-Catalyzed Oxidation of gem-Difluoroalkenes Generate α,α-Difluorinated-α-Phenoxyketones

Koley, S.; Cayton, K. T; González-Montiel, G. A.; Yadav, M. R.; Orsi, D. L.; Intelli, A. J; Cheong, P. H.-Y.;* Altman, R. A.*

J. Org. Chem. 2022, 87, 10710–10725.

42. Fluorine-Retentive Strategies for the Functionalization of gem-Difluoroalkenes
42. Fluorine-Retentive Strategies for the Functionalization of gem-Difluoroalkenes

Sorrentino, J. P.; Altman, R. A.*

Synthesis 2021, 53, 3935–3950.

41. Acid-catalyzed Hydrothiolation of gem-Difluorostyrenes to Access α,α-Difluoroalkylthioethers
41. Acid-catalyzed Hydrothiolation of gem-Difluorostyrenes to Access α,α-Difluoroalkylthioethers

Sorrentino, J. P.; Orsi, D. L.; Altman, R. A.*

J. Org. Chem. 2021, 86, 2297–2311.

39. Arylation of gem-difluoroalkenes using a Pd/Cu Co-catalytic system that avoids β-fluoride elimination
39. Arylation of gem-difluoroalkenes using a Pd/Cu Co-catalytic system that avoids β-fluoride elimination

Yuan, K; Feoktistova, T.; Cheong, P. H.-Y.;* Altman, R. A.*

Chem. Sci. 2021, 12, 1363–1367.

38. Cobalt-Catalyzed Selective Unsymmetric Dioxidation of β,β-Difluorostyrenes
38. Cobalt-Catalyzed Selective Unsymmetric Dioxidation of β,β-Difluorostyrenes

Orsi, D. L.; Sorrentino, J. P.; Douglas, J. T.; Altman, R. A.*

J. Org. Chem. 2020, 85, 10451–10465.

36. Recent Advances in Transition Metal Catalyzed Functionalization of gem-Difluoroalkenes
36. Recent Advances in Transition Metal Catalyzed Functionalization of gem-Difluoroalkenes

Koley, S.; Altman, R. A.*

Isr. J. Chem. 2020, 60, 313–339.

32. Organocatalytic Strategy for Hydrophenolation of gem-Difluoroalkenes
32. Organocatalytic Strategy for Hydrophenolation of gem-Difluoroalkenes

Orsi, D. L.; Yadav, M. R.; Altman, R. A.*

Tetrahedron 2019, 75, 4325–4336.

25. Base Catalysis Enables Access to α,α-Difluoroalkylthio-ethers
25. Base Catalysis Enables Access to α,α-Difluoroalkylthio-ethers

Orsi, D. L.; Easley, B. J.; Lick, A. M.; Altman, R. A.*

Org. Lett. 2017, 19, 1570–1573.

18. Metal-free Trifluoromethylation of Aromatic and Heteroaromatic Aldehydes and Ketones
18. Metal-free Trifluoromethylation of Aromatic and Heteroaromatic Aldehydes and Ketones

Qiao, Y.; Si, T.; Yang, M.-H.; Altman, R. A.*

J. Org. Chem. 2014, 79, 7122–7131.

13. Preparation of Fluoroalkenes via the Shapiro Reaction: Direct Access to Fluorinated Peptidomimetics
13. Preparation of Fluoroalkenes via the Shapiro Reaction: Direct Access to Fluorinated Peptidomimetics

Yang, M. H.; Matikonda, S. S.; Altman, R. A.*

Org. Lett. 2013, 15, 3894–3897.

Synthetic Organic Methodology