17. Copper-catalyzed Conversion of Propargylic Bromodifluoroacetates to Trifluoromethanes
Ambler, B. R.; Peddi, S.; Altman, R. A.*
Synthesis 2014, 46, 1938–1946.
The development of efficient methods for accessing fluorinated functional groups is desirable. Herein, we report a two-step method that utilizes catalytic copper for the decarboxylative trifluoromethylation of propargyl bromodifluoroacetates is described. This protocol affords a mixture of propargyl trifluoromethanes and trifluoromethyl allenes.