30. Catalytic One-Step Deoxytrifluoromethylation of Alcohols

Organofluorine MethodologyDecarboxylative and Deoxygenative Fluoroalkylation CouplingSynthetic Organic MethodologyPre 2020
Written By Altmaniacs
 
 

de Azambuja, F.; Lovrien, S. K.; Ross, P.; Ambler, B. R.; Altman, R. A.*

J. Org. Chem. 2019, 84, 2061–2071.

A new bench-stable trifluoromethylation reagent, phenyl bromodifluoroacetate, converts readily available alcohols to trifluoromethanes in a Cu-catalyzed deoxytrifluoromethylation reaction. This reaction streamlines access to target biologically active molecules, and should be useful for a variety of medicinal, agricultural, and materials chemists.

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29. Synthesis of Leu-Enkephalin Peptidomimetics Containing Trifluromethylalkenes as Amide Isopolar Mimics